ABSTRACT
Objective: To investigate the biological effects of histone deacetylase inhibitors (HDACIs) suberoylanilide hydroxamic acid (SAHA) combined with vincristine (VCR) on the ovarian cancer SKOV3 cells, and to clarify their mechanisms. Methods: The human ovarian cancer SKOV3 cells were divided into control group, SAHA group, VCR group and SAHA+VCR group. CCK-8 method was used to detect the surival rates of SKOV3 cells in various groups. The apoptotic rates, the autophagy rates and the distribution of cell cycles of SKV03 cells in various groups were detected by flow cytometry (FCM). Results: The CCK-8 results showed that compared with control group, the survival rates of SKOV3 cells in SAHA group and VCR group were decreased significantly. Compared with VCR group or SAHA group, the survival rates of cells in SAHA + VCR groups were decreased significantly (P